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How to Effectively and Safely Increase Your Dose on Semaglutide and Tirzepatide The numbers from Lilly's Phase 3 retatrutide trial dropped this week and I haven't been able to stop thinking about them. Not only as a doctor but as a long term GLP 1 user Semaglutide vs Tirzepatide, same medication class, different receptor targets. Here's what that actually means. Semaglutide targets the GLP 1 receptor, found in the brain, gut, and pancreas. Tirzepatide targets two: GLP 1 and GIP. The weight loss independent hepatoprotective benefits of semaglutide are orchestrated by intrahepatic sinusoidal endothelial GLP 1 receptors. https: t.co xnMLLYA9bR
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4.4 ★★★★★
Based on 398 reviews
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Product Reviews
★★★★★ 3
Dog Loves It, But Durability/Safety Major Issue
Size: 8 Inch, Color: Tree Branch
My 9 month old Frenchie loves it, but she got pretty sick this weekend and was vomiting all day...next day she finally threw up a big chunk of this toy...just beware if your dog is a heavy chewer, this may not be the right fit for you. Not the best durability...
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Reviewed in the United States on April 20, 2026
★★★★★ 5
She loves them, therefore I love them too
Size: 5.5 Inch, Color: Ring Toy
My furbaby LOVES these, especially the peanut butter flavored ones. I still regularly brush her teefers, but these do help with dental care.
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Reviewed in the United States on June 6, 2026
★★★★★ 1
Made mostly of POLYPROPYLENE PLASTIC and should not be injested.
Size: 8 Inch - 2 Pack, Color: Tree Branch
BAD PRODUCT. DO NOT BUY THESE FOR YOUR DOG. They are made mostly of POLYPROPYLENE PLASTIC. It even says on the package - "CAUTION: Product is not intended to be eaten or ingested. If you believe your pet has swallowed a piece, please take away and contact veterinarian if needed.
Our dachshund went to town on one of these and had diarrhea for two days and cost us several hundred dollars in vet bills to do x-rays and medicine for the poor dog. What do you think a dog is going to do with a dog chew? Just find another product. This one isn't worth it.
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Reviewed in the United States on May 26, 2026
★★★★★ 5
Loved by both my pup and I! I can't say enough good things!!
Size: Large, Number of Items: 1
My lab puppy absolutely loves this! And so do I. My 5 month old lab puppy loves to play with us and is not so good at playing by himself. Though he is getting a little better. I use this when we need to keep him occupied or when we need a little break. I bought this for him when we first got him at about 2 months old; even then he had no problems figuring it out. Depending on how much food I put in it, this will keep him busy for quite awhile. My puppy does not usually have much of an attention span, he is always jumping from one toy, bone, or chew to another. But with this I know I can consistently depend on him being entertained for at least 15 to 30 minutes, again, depending on how much food I put in there.
"Bob" as we call him, is very well made. I purchased the large one and it holds about 2 cups of food. The yellow top screws off so that you can pour the food in, there is an adjustable opening so if you want to make it harder for your dog you can adjust it and he will have to work harder to get the food out. It screws on quite tight and has never come off while my dog is playing with it even when he carries it around by the top. There is another opening towards the bottom where the food comes out that is also adjustable depending on how easy you want it to be or how big the food is that you are using. Both openings are pretty large and I have never had an issue with putting things in there. I know some people use it to put their dog's food in, as my dog is self fed I have never done that. But I do use Cheerios and all kinds of other cereals and treats but mainly I use other "special" dog foods. I buy moist and dry dog foods that look like they may taste good and use them as treats. My dog thinks he is getting treats and never knows the difference, he loves them. It's healthier than feeding him lots of treats and also a lot cheaper. Using the "Bob" not only keeps him independently entertained but also helps to tire him out. It can be a bit loud as I have tile floors but it is not that bad.
It is constructed extremely well. My pup plays very rough with it, he bats it around into walls, furniture etc., drops it down steps, it has taken a beating but it has stood up to my dog's abuse, where many of his other toys have not made it. It is very easy to clean.
I plan on purchasing another one for my sister-in-law's pig. She is 70 pounds over weight and hates to move around but obviously loves food. I think that putting her food inside will be just the motivation she needs. And it is so well made that I don't have to worry about giving it to her!
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Reviewed in the United States on August 10, 2014
★★★★★ 5
Favorite toy
Size: Small, Number of Items: 1, Size: Small, Number of Items: 1
This is my dog’s absolute favorite toy. When I fill it, it’ll keep him busy for up to an hour, and even when I don’t fill it, he likes to tip it around to check for missed treats quite often. It’s super sturdy, and just the right size for him (20 lb mini schnauzer).
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Reviewed in the United States on April 18, 2026
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